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Professor Bart CJM Fauser

Professor Bart CJM Fauser, M

Bart Fauser is Professor of Reproductive Medicine at the University of Utrecht in The Netherlands and Chair of the Division of Woman & Baby (Departments of Reproductive Medicine & Gynecology, Obstetrics, Neonatology) at the University Medical Center in Utrecht (since 2004).

He is a former Professor of Reproductive Endocrinology and Director of the Center of Reproductive Medicine at the Erasmus Medical Center in Rotterdam (1996-2003); Visiting Professor, University Southampton, UK (since 2010); Saal van Zwanenberg Professor, Center of Reproductive Medicine, Free University, Brussels (2003-2008); Visiting Professor, Stanford School of Medicine, Palo Alto, California (1993-1995); and Fulbright post-doctoral Scholar, University of California, San Diego, California (1987-1988).

From 2001-2007, Professor Fauser was the Editor-in-Chief of 'Human Reproduction Update.' He has published around 300 PubMed papers (Hirsch factor 52). Professor Fauser serves on many international editorial boards and has been active in many international societies. His work has been widely covered in national and international news media. His major research interest is pathophysiology of human ovarian function.


Project: Endometrial gene expression profile associated with recurrent implantation failure.

Despite major advances in IVF treatment and embryo culture and selection techniques, the majority of IVF cycles do not result in pregnancy. The role of the endometrium as a determinant of successful implantation is therefore being increasingly recognized. However, to date no robust diagnostic test for endometrial receptivity has been developed, and no drug intervention has been shown to improve receptivity. Understanding the genomic footprint of the highly refractory human endometrium would provide a major step forward. Our group has recently identified a profile of 70 genes which are highly dysregulated in women with who fail to achieve implantation despite the transfer of multiple high quality embryos after IVF. However, before this information can be developed into a diagnostic test of endometrial receptivity, or indeed provide reliable pointers for new clinical interventions, the profile needs to be tested in a separate population. 

The GFI Grant has made it possible for us to perform this validation study.